Blood mixing and tranfusions has been studied for a long time, but many have led to fatal accidents. The reason is because mixing blood can cause blood clumping or agglutination. Karl Landsteiner discovered that blood clumping was a result of the antibodies of the blood tranfusion receiver was fighting against donar blood cells. Since then, blood mixing and tranfusions have become much safer.
Here is a chart of all the possible blood transfusions:
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